Synlogic and Caldera Therapeutics Announce Definitive Merger Agreement

July 29, 2026

Synlogic and Caldera Therapeutics entered into a definitive all-stock merger agreement to combine into a newly formed holding company, with the combined company operating as Caldera Therapeutics, Inc. The transaction is expected to close in early 2027 and includes a concurrent upsized private placement expected to generate approximately $278 million to fund Phase 2 development of CLD-423.

Buyers
Caldera Therapeutics, Inc., Synlogic, Inc., Newly formed holding company (to operate as Caldera Therapeutics, Inc.)
Targets
Synlogic, Inc., Caldera Therapeutics, Inc.
Location
Massachusetts, United States
Transaction Type
Buyout

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